At Diagnopein Diagnostic, we offer high-accuracy PCR-based molecular testing for the Factor-V Leiden Mutation. Our advanced laboratory supports reliable genetic screening, making i
Factor-V Leiden Mutation is a hereditary genetic variation in the F5 gene that increases the risk of developing abnormal blood clots. This mutation makes Factor-V resistant to breakdown by activated Protein C, leading to excessive clot formation in veins. The condition is one of the most common causes of inherited thrombophilia, and early detection is important for preventing complications like Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE).
The Factor-V Leiden Mutation is the leading genetic cause of unusual blood clot formation. People with this condition may experience clots at a young age or without any obvious reason. If left undiagnosed, it can lead to life-threatening conditions.
You should consider a Factor-V Leiden test if you have:
A personal or family history of blood clots
Unexplained Deep Vein Thrombosis (DVT)
Pulmonary Embolism (PE) without known cause
Recurrent pregnancy loss or miscarriages
Complications like preeclampsia during pregnancy
Early-age clotting before the age of 50
Using birth control pills or hormone therapy
Planning major surgery and want to evaluate clot risk
This genetic test helps identify individuals with heterozygous or homozygous mutations. Homozygous individuals are at higher risk and require closer monitoring. Knowing your mutation status guides necessary preventive care, medication decisions, and lifestyle modifications.
Testing for this mutation offers multiple important benefits:
Early identification helps prevent life-threatening conditions such as DVT and PE.
Doctors can prescribe anticoagulant medicines or preventive treatment based on mutation severity.
Women with the mutation may face increased risk of miscarriage, fetal growth issues, or clotting during pregnancy. Testing helps gynecologists provide safe, guided pregnancy care.
Since this is an inherited mutation, family members can also get evaluated if one person tests positive.
Knowing the risk helps in taking preventive measures during surgeries, long flights, or prolonged bed rest.
Testing at Diagnopein is simple and followed by accurate reporting.
A small blood sample is taken by trained phlebotomists at the nearest Diagnopein center or through home collection.
DNA is extracted from the sample and the F5 gene is analyzed using PCR or molecular methods.
The lab checks if the mutation is:
Heterozygous – One mutated copy
Homozygous – Two mutated copies (higher risk)
Results include clear explanations to help doctors plan your treatment or preventive strategy.
Parameters Covered
F5 Gene Mutation (G1691A)
APC Resistance evaluation
Thrombophilia genetic risk assessment
Advanced molecular laboratory
Highly accurate PCR-based testing
Affordable pricing across all centers
Experienced pathologists & genetic experts
Quick turnaround time
Home collection available
30+ centers across Pune, Mumbai, Nanded, Nagpur, Nashik, and Karad
Trusted diagnostic brand for accurate genetic screening
With Diagnopein, every report undergoes strict quality checks to ensure precision, reliability, and clarity.
While there is no cure for the mutation itself, management strategies include anticoagulant medications (blood thinners) to reduce the risk of clot formation, especially after surgery or during pregnancy.
A healthcare provider will take a blood sample, usually from a vein in your arm. The sample is then sent to a laboratory for analysis.
It is one of the most common inherited forms of thrombophilia, especially in individuals of European descent, with about 5% to 10% of this population carrying the mutation.
The Factor V Leiden mutation test is generally safe, but as with any blood draw, there may be minor risks such as bruising, bleeding, or infection at the puncture site.
