Free lambda light chains (FLC) are essential proteins produced by plasma cells, which are a type of white blood cell responsible for producing antibodies.
These light chains are part of immunoglobulins (Ig), the body's defense mechanisms against infections and diseases. In healthy individuals, free lambda light chains circulate in the blood, usually in balance with kappa light chains. However, imbalances in these proteins can indicate various health issues, particularly plasma cell disorders, including multiple myeloma and amyloidosis.
1] Detection of Plasma Cell Disorders: - Free lambda light chains are particularly significant in diagnosing plasma cell disorders such as multiple myeloma, where there is an overproduction of one type of light chain. Abnormal levels of free lambda light chains can indicate the presence of malignant plasma cells.
2] Monitoring Disease Progression: - For patients diagnosed with plasma cell disorders, monitoring free lambda light chain levels helps evaluate treatment efficacy and disease progression. A decrease in light chain levels can signify a positive response to treatment, while increasing levels may suggest disease progression or relapse.
3] Distinguishing Between Conditions: - The measurement of free lambda light chains, particularly in conjunction with kappa light chains, helps in differentiating between various plasma cell disorders. For example, a high lambda to kappa ratio may indicate lambda light chain myeloma, while a low ratio could suggest kappa light chain myeloma.
The free lambda light chain test pune is typically performed through a blood draw. Here’s a brief overview of the procedure:
1] Preparation:- No special preparation is usually required for the test, but patients should inform their healthcare provider of any medications or supplements they are taking.
2] Blood Collection:- A healthcare professional will collect a blood sample from a vein in the arm using a sterile needle. The sample is then sent to a laboratory for analysis.
3] Laboratory Analysis:- In the laboratory, the blood sample is analyzed to measure the levels of free lambda light chains and often the kappa light chains, allowing for the calculation of the kappa/lambda ratio.
1] Normal Levels:- The normal range for free lambda light chains is typically between 5.7 to 26.3 mg/L, but this can vary by laboratory standards.
2] Abnormal Levels:- High Free Lambda Light Chains: Elevated levels may indicate multiple myeloma, light chain amyloidosis, or other plasma cell disorders. Low Free Lambda Light Chains: Reduced levels can occur due to various conditions, including renal insufficiency or can be seen in some autoimmune diseases.
3] Kappa/Lambda Ratio:- The kappa/lambda ratio is crucial in diagnosing plasma cell disorders. Normal ranges are generally between 0.26 to 1.65. Deviations from this range can indicate an underlying disease.
At Diagnopein, we offer comprehensive, accurate, and timely diagnostic services, including the Free Lambda (Light Chain) Test pune. With our NABL-accredited labs, cutting-edge technology, and skilled technicians, you can be assured of reliable results every time. Get your results quickly, especially when time is crucial in detecting severe infections.
Competitive pricing without compromising on quality. Our team of experienced professionals ensures the test is conducted smoothly with minimal discomfort. We provide not just Free Lambda (Light Chain) test results but insights into your health condition, helping you and your doctor make informed decisions about treatment. For more information call us at +91 9204 108108.
Since the kidneys filter light chains from the blood, impaired kidney function can alter light chain levels. Therefore, kidney function should be assessed alongside light chain measurements to provide a complete picture of the patient's health.
<p>The risks associated with a blood draw are minimal but may include:<br> A] Bruising at the site of the blood draw.<br> B] Fainting or feeling lightheaded.<br> C] Infection at the puncture site (rare).</p>
The test is conducted through a simple blood draw. A healthcare professional collects a blood sample from a vein in your arm, which is then sent to a laboratory for analysis.
No special preparation is usually required for this test. However, inform your healthcare provider about any medications or supplements you are taking, as they may affect the results.
