Ascitic fluid is the liquid that accumulates in the peritoneal cavity, the space between the abdominal organs and the peritoneal lining.
Ascitic fluid cytology is a diagnostic procedure that involves examining the fluid from the peritoneal cavity (the area that surrounds the organs in the abdomen) to detect any abnormal cells, infections, or diseases. The procedure is commonly used to evaluate ascites, a condition where fluid accumulates in the abdomen. Ascitic fluid cytology can provide crucial information for diagnosing the underlying cause of ascites, including infections, cancers, and liver diseases.
Ascitic fluid cytology is performed when a doctor suspects that ascites is caused by an underlying condition such as liver disease, infection, or cancer. Some of the most common reasons for performing ascitic fluid cytology include:
1] To evaluate ascites: The presence of fluid in the abdomen can be a sign of various diseases. Cytology helps to differentiate between different causes, including whether the ascites is caused by cirrhosis, cancer, or an infection.
2] To diagnose cancer: Cancer, especially ovarian cancer, liver cancer, and pancreatic cancer, often leads to the development of ascites. Cytology can help detect malignant cells in the ascitic fluid, which may confirm a diagnosis of cancer.
3] To identify infections: Ascites can sometimes be caused by infections like spontaneous bacterial peritonitis (SBP). Cytology can help identify the presence of bacteria or white blood cells, which indicate an infection.
4] To rule out other causes of ascites: By examining the cytology of ascitic fluid, doctors can rule out causes such as tuberculosis, heart failure, and kidney disease, which may also lead to ascites.
1] Malignant cells: If cancer cells are found, it suggests the ascites is likely due to metastatic cancer or primary peritoneal cancer.
2] High white blood cell count: If the fluid contains a large number of white blood cells, especially neutrophils, it could indicate an infection, such as spontaneous bacterial peritonitis (SBP).
3] Normal cells: In some cases, ascitic fluid may contain normal or reactive mesothelial cells, indicating that the ascites is likely due to a non-cancerous condition such as cirrhosis or heart failure.
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It is performed to identify the cause of ascites (fluid accumulation in the abdomen), such as infections (e.g., spontaneous bacterial peritonitis), liver cirrhosis, or abdominal cancers.
The test can detect malignant cells (suggesting cancer), infection (bacteria, fungi), or signs of inflammation (such as white blood cells). It helps diagnose conditions like cancer or spontaneous bacterial peritonitis.
Yes, the test is generally safe, though the needle insertion for fluid collection may cause mild discomfort or bruising.
A sample of ascitic fluid is collected using a procedure called paracentesis, where a needle is inserted into the abdomen to withdraw the fluid, which is then sent to a lab for microscopic examination.