The Anti-Neutrophil Cytoplasmic Antibody (ANCA) Test measures the levels of ANCAs in the blood.
High levels of these antibodies can indicate the presence of autoimmune conditions, especially small and medium-sized vessel vasculitis. The test helps differentiate between types of autoimmune disorders by identifying which specific antibodies are present and is crucial for accurate diagnosis and treatment planning.
1] P-ANCA (Perinuclear ANCA):
A] Target Antigen: Primarily directed against myeloperoxidase (MPO).
B] Associated Conditions: Commonly found in Microscopic Polyangiitis and Churg-Strauss Syndrome.
C] Test Significance: p-ANCA positivity often indicates conditions affecting smaller blood vessels, especially in the kidneys and lungs.
2] C-ANCA (Cytoplasmic ANCA):
A] Target Antigen: Primarily directed against proteinase-3 (PR3).
B] Associated Conditions: Highly associated with Granulomatosis with Polyangiitis (GPA), formerly known as Wegener’s Granulomatosis.
C] Test Significance: c-ANCA positivity is a strong indicator of GPA and is primarily seen in conditions affecting both the respiratory tract and kidneys.
The results of the ANCA test can be complex and often need to be interpreted along with clinical symptoms, imaging studies, and other laboratory tests:
1] Positive ANCA Results: A positive result for either p-ANCA or c-ANCA indicates a higher likelihood of autoimmune vasculitis or similar inflammatory disorders.
2] Negative ANCA Results: If the test returns negative for both, it does not necessarily rule out vasculitis but makes it less likely.
You should choose Diagnopein for your ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES(P-ANCA + C-ANCA) test because we are committed to providing high-quality diagnostic care in a clean and hygienic environment. Our center is equipped with advanced technology to ensure accurate and reliable test results, which are crucial for assessing this test. Diagnopein’s experienced staff is dedicated to handling tests with precision and care, offering you both expertise and comfort. We also offer affordable pricing, making essential health diagnostics accessible without compromising quality. For timely, professional, and affordable cardiac testing, Diagnopein is your trusted partner for your healthcare.
Your doctor may also request tests for other antibodies, kidney function tests, or imaging studies for a comprehensive diagnosis.
No, fasting is not typically required for an ANCA test, but follow any instructions given by your healthcare provider.
Results are usually available within a few days, but exact timelines may vary depending on the lab and testing facility.
While ANCA is not typically used to diagnose autoimmune hepatitis, it may be part of a larger panel if autoimmune vasculitis is suspected.
